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Metallo-Foldamers with Backbone-Coordinative Oxime Peptides: Control of Secondary Structures

Authors

  • Dr. Shohei Tashiro,

    1. Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan)
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  • Koji Matsuoka,

    1. Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan)
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  • Ai Minoda,

    1. Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan)
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  • Prof. Dr. Mitsuhiko Shionoya

    Corresponding author
    1. Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan)
    • Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan)
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  • This study was supported by KAKENHI, the Japan Society for the Promotion of Science and MEXT (Japan). We thank Dr. J.-L. Duprey for his helpful discussion.

Abstract

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Metal-mediated secondary structures of peptide-based foldamers were constructed using artificial backbone-coordinative oxime peptides. Complexation of the peptides with PdII afforded several mononuclear and dinuclear secondary structures such as helices and hairpins as confirmed by single-crystal XRD and NMR analyses (see picture).

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