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Communication

DNA Aptamer-Mediated Cell Targeting†

  1. Xiangling Xiong1,
  2. Dr. Haipeng Liu1,
  3. Dr. Zilong Zhao2,
  4. Dr. Meghan B. Altman1,
  5. Dr. Dalia Lopez-Colon1,
  6. Prof. Chaoyong James Yang3,*,
  7. Prof. Lung-Ji Chang1,
  8. Prof. Chen Liu1,
  9. Prof. Weihong Tan1,2,*

Article first published online: 11 DEC 2012

DOI: 10.1002/anie.201207063

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 52, Issue 5, pages 1472–1476, January 28, 2013

Additional Information

How to Cite

Xiong, X., Liu, H., Zhao, Z., Altman, M. B., Lopez-Colon, D., Yang, C. J., Chang, L.-J., Liu, C. and Tan, W. (2013), DNA Aptamer-Mediated Cell Targeting . Angew. Chem. Int. Ed., 52: 1472–1476. doi: 10.1002/anie.201207063

Author Information

  1. 1

    Departments of Chemistry, of Physiology and Functional Genomics, of Molecular Genetics and Microbiology, and of Pathology and Laboratory Medicine, Shands Cancer Center, Center for Research at the Bio/nano Interface, University of Florida, Gainesville, FL 32611-7200 (USA)

  2. 2

    Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082 (P.R. China)

  3. 3

    State Key Laboratory for Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China)

*State Key Laboratory for Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China)

  1. †

    This work is supported by grants awarded by the National Institutes of Health (GM066137, GM079359 and CA133086), by the National Key Scientific Program of China (2011CB911000), the China National Instrumentation Program (2011YQ03012412), and the Foundation for Innovative Research Groups of NSFC (21221003).

Publication History

  1. Issue published online: 23 JAN 2013
  2. Article first published online: 11 DEC 2012
  3. Manuscript Received: 31 AUG 2012

Funded by

  • National Institutes of Health. Grant Numbers: GM066137, GM079359, CA133086
  • National Key Scientific Program of China. Grant Number: 2011CB911000
  • China National Instrumentation Program. Grant Number: 2011YQ03012412
  • Foundation for Innovative Research Groups of NSFC. Grant Number: 21221003

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Keywords:

  • aptamers;
  • cell modification;
  • cell recognition;
  • cell-based immunotherapy;
  • DNA
Thumbnail image of graphical abstract

An apt modification: A simple and effective way to modify the cell surface with target-specific ligands, such as DNA aptamers, while minimizing the effects on the modified cells has been developed. After incubating with lipo–aptamer probes, immune cells (red, see scheme) recognize and kill cancer cells (blue) in the cell mixture.

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