Get access

Dienamine-Mediated Inverse-Electron-Demand Hetero-Diels–Alder Reaction by Using an Enantioselective H-Bond-Directing Strategy


  • This work was made possible by grants from OChemSchool, Carlsberg Foundation, FNU, and Aarhus University. C.R.-E. thanks the Generalitat de Catalunya for a Beatriu de Pinós postdoctoral fellowship. We thank Dr. Jacob Overgaard for performing X-ray analysis.


original image

Giving directions: Optically active dihydropyrans bearing three contiguous stereogenic centers can be efficiently prepared by the title reaction. High stereo- and regiocontrol can be achieved by employing a bifunctional H-bond-directing aminocatalyst.