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Keywords:

  • nucleosides;
  • riboswitch;
  • RNA;
  • solid-phase synthesis;
  • trifluoromethylation
Thumbnail image of graphical abstract

Fluorishing: The Togni reagent allows efficient synthetic access to fluorine-labeled RNA molecules (see picture). These are in turn highly useful for NMR spectroscopic analyses of secondary and tertiary structures, RNA–protein interactions, and functionality of riboswitch modules.