Get access

MRI Visualization of Melanoma Cells by Targeting Overexpressed Sialic Acid with a GdIII-dota-en-pba Imaging Reporter

Authors


  • This research was performed in the framework of the EU COST Action TD1004, “Theranostics Imaging and Therapy: an Action to Develop Novel Nanosized Systems for Imaging-Guided Drug Delivery”, and supported by Regione Piemonte (PIIMDMT and nano-IGT projects), MIUR (PRIN 2009235JB7). The authors are grateful to Dr. Joop A. Peters for valuable scientific discussions. dota=1,4,7,10-tetraazacyclododecane 1,4,7,10-tetraacetate, en=ethylenediamine, pba=phenylboronic acid.

Abstract

original image

By design: The novel MRI reporter GdIII-dota-en-pba (see picture) selectively binds to sialic acid residues, which are overexpressed on tumors. This imaging reporter accumulates in a murine melanoma B16-F10 mice xenograft and from the MRI signal intensity it is possible to quantify the sialic acid concentration that is directly associated with tumor malignancy.

Get access to the full text of this article

Ancillary