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Copper-Catalyzed Silacarboxylation of Internal Alkynes by Employing Carbon Dioxide and Silylboranes


  • This work was supported by Grant-in-Aid for Scientific Research on Innovative Areas (“Organic synthesis based on reaction integration” and “Molecular activation directed toward straightforward synthesis”) from MEXT (Japan).


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Silalactones: The copper-catalyzed reaction of internal alkynes with (dimethylphenylsilyl)pinacolborane (Me2PhSi-B(pin)) as the silicon source and CO2 at atmospheric pressure afforded silalactones selectively in good to high yields. The silalactones can be used as substrates for the Hiyama cross-coupling reaction as demonstrated for one substrate.