Construction of a Photoactivated Insulin Depot


  • We would like to thank Prof. William Gutheil for guidance on mass spectrometry issues.


original image

Light controlled: A material that allows for insulin to be released in a controlled fashion by using light was prepared. A subcutaneous reservoir of such materials could allow for the non-invasive control of blood sugar. Insulin (blue in picture) was linked to an insoluble resin (green) through a photocleavable linker (red). Native insulin is released following a first-order process in response to pulses of light from an LED.