Construction of a Photoactivated Insulin Depot

Authors


  • We would like to thank Prof. William Gutheil for guidance on mass spectrometry issues.

Abstract

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Light controlled: A material that allows for insulin to be released in a controlled fashion by using light was prepared. A subcutaneous reservoir of such materials could allow for the non-invasive control of blood sugar. Insulin (blue in picture) was linked to an insoluble resin (green) through a photocleavable linker (red). Native insulin is released following a first-order process in response to pulses of light from an LED.

Ancillary