SEARCH

SEARCH BY CITATION

Keywords:

  • cancer;
  • drug delivery;
  • nanoparticles;
  • polymerization;
  • prodrugs
Thumbnail image of graphical abstract

Magic rubber bullets: Novel anticancer nanoparticles made of well-defined polymer–drug conjugate amphiphiles are prepared by the controlled growth of a hydrophobic polyisoprene chain from a drug macroinitiator by using nitroxide-mediated polymerization (NMP; see picture). The resulting conjugates self-assembled into nanoparticles exhibiting high drug payloads and significant anticancer activities both in vitro and in vivo.