The research leading to these results was funded by the European Research Council under the European Community’s Seventh Framework Programme FP7/2007-2013 (Grant Agreement No. 249835). We thank Arkema for the BlocBuilder MA alkoxyamine, Service de Microscopie Electronique (IFR de Biologie Intégrative) for the cryo-TEM, and Service d’Analyses des Médicaments et Métabolites for the ESI MS. CNRS and the French Ministry of Research are also acknowledged for financial support.
Nanoparticles with In Vivo Anticancer Activity from Polymer Prodrug Amphiphiles Prepared by Living Radical Polymerization†
Article first published online: 17 DEC 2012
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 6, pages 1678–1682, February 4, 2013
How to Cite
Harrisson, S., Nicolas, J., Maksimenko, A., Bui, D. T., Mougin, J. and Couvreur, P. (2013), Nanoparticles with In Vivo Anticancer Activity from Polymer Prodrug Amphiphiles Prepared by Living Radical Polymerization . Angew. Chem. Int. Ed., 52: 1678–1682. doi: 10.1002/anie.201207297
- Issue published online: 1 FEB 2013
- Article first published online: 17 DEC 2012
- Manuscript Received: 10 SEP 2012
- European Research Council. Grant Number: 249835
- French Ministry of Research
- drug delivery;
Magic rubber bullets: Novel anticancer nanoparticles made of well-defined polymer–drug conjugate amphiphiles are prepared by the controlled growth of a hydrophobic polyisoprene chain from a drug macroinitiator by using nitroxide-mediated polymerization (NMP; see picture). The resulting conjugates self-assembled into nanoparticles exhibiting high drug payloads and significant anticancer activities both in vitro and in vivo.