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Keywords:

  • C-F bond activation;
  • desymmetrization;
  • fluorine;
  • silicon;
  • sodium
Thumbnail image of graphical abstract

How to lose fluorine: Biologically relevant oxazolidinones 1 were synthesized through the desymmetrization of unactivated aliphatic difluorides by Si-induced catalytic C[BOND]F bond-cleavage using BSA/CsF (BSA=bis(trimethylsilyl)acetamide). The direct transformation of 2 with isocyanates into 1 by cascade carbamoylation/cyclization, in which cyclization is induced by Na-assisted C[BOND]F bond activation, was also achieved.