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Metal-Locked DNA Three-Way Junction


  • We acknowledge support from the Global COE program for Chemistry Innovation through Cooperation of Science and Engineering, a Grant-in-Aid for Scientific Research (S) (No. 21225003) from MEXT of Japan for M.S., and a Grant-in Aid for Young Scientists (B) (No. 23750181) for Y.T.


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Three-way split: A postsynthetic click reaction has resulted in the conjugation of three bipyridine ligands at the core of a DNA three-way junction structure (see picture). Melting curve analyses revealed that NiII ions significantly stabilize the junction structure through the formation of a [Ni(bpy)3]2+ complex which cross-links three strands. The metal complex shows a diastereomeric preference, thus indicating a chirality transfer from the DNA.