Catalytic Enantioselective Synthesis of Alkenylhydrosilanes


  • This research was supported by JSPS (KAKENHI 24350048, 23655086), Global COE Program (Kyushu Univ.), Management Expenses Grants for National Universities Corporations, MEXT: Project of Integrated Research on Chemical Synthesis, and the Nagase Science and Technology Foundation. We thank the Takasago International Corp. for their gift of chiral bidentate phosphine ligands, Y. Kawasaki (Kyushu Univ.) for his technical support, and Y. Tanaka (IMCE, Kyushu Univ.) for the HRMS measurements.


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Asymmetric silanes: A synthesis of nonracemic alkenylhydrosilanes has been developed based on the desymmetrization of a dihydrosilane through alkenylation with an alkyne using an asymmetric catalyst. The alkenylhydrosilane product can be used as a versatile chiral building block for other functionalized nonracemic silanes through the stereoselective conversion of its hydride and/or alkenyl moiety.