This research was supported by JSPS (KAKENHI 24350048, 23655086), Global COE Program (Kyushu Univ.), Management Expenses Grants for National Universities Corporations, MEXT: Project of Integrated Research on Chemical Synthesis, and the Nagase Science and Technology Foundation. We thank the Takasago International Corp. for their gift of chiral bidentate phosphine ligands, Y. Kawasaki (Kyushu Univ.) for his technical support, and Y. Tanaka (IMCE, Kyushu Univ.) for the HRMS measurements.
Catalytic Enantioselective Synthesis of Alkenylhydrosilanes†
Article first published online: 7 NOV 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 51, pages 12745–12748, December 14, 2012
How to Cite
Igawa, K., Yoshihiro, D., Ichikawa, N., Kokan, N. and Tomooka, K. (2012), Catalytic Enantioselective Synthesis of Alkenylhydrosilanes . Angew. Chem. Int. Ed., 51: 12745–12748. doi: 10.1002/anie.201207361
- Issue published online: 10 DEC 2012
- Article first published online: 7 NOV 2012
- Manuscript Received: 12 SEP 2012
- JSPS. Grant Numbers: 24350048, 23655086
- asymmetric synthesis;
Asymmetric silanes: A synthesis of nonracemic alkenylhydrosilanes has been developed based on the desymmetrization of a dihydrosilane through alkenylation with an alkyne using an asymmetric catalyst. The alkenylhydrosilane product can be used as a versatile chiral building block for other functionalized nonracemic silanes through the stereoselective conversion of its hydride and/or alkenyl moiety.