The authors acknowledge the financial support of this work from the NIH (GM-58108).
Highly Reactive, Single-Component Nickel Catalyst Precursor for Suzuki–Miyuara Cross-Coupling of Heteroaryl Boronic Acids with Heteroaryl Halides†
Article first published online: 7 NOV 2012
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 51, Issue 51, pages 12837–12841, December 14, 2012
How to Cite
Ge, S. and Hartwig, J. F. (2012), Highly Reactive, Single-Component Nickel Catalyst Precursor for Suzuki–Miyuara Cross-Coupling of Heteroaryl Boronic Acids with Heteroaryl Halides . Angew. Chem. Int. Ed., 51: 12837–12841. doi: 10.1002/anie.201207428
- Issue published online: 10 DEC 2012
- Article first published online: 7 NOV 2012
- Manuscript Received: 14 SEP 2012
- NIH. Grant Number: GM-58108
- homogeneous catalysis;
- synthetic methods
One for all: The coupling of a range of nitrogen- and sulfur-containing heteroaryl halides with five-membered nitrogen-, oxygen-, and sulfur-containing heteroaryl boronic acids were achieved in high yields with only 0.5 mol % of the single-component nickel precatalyst [(dppf)NiCl(cinnamyl)] (dppf=1,1′-bis(diphenylphosphanyl)ferrocene). The reaction demonstrates good functional group compatibility, and is easily conducted on a large scale without a dry box.