Highly Reactive, Single-Component Nickel Catalyst Precursor for Suzuki–Miyuara Cross-Coupling of Heteroaryl Boronic Acids with Heteroaryl Halides


  • The authors acknowledge the financial support of this work from the NIH (GM-58108).


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One for all: The coupling of a range of nitrogen- and sulfur-containing heteroaryl halides with five-membered nitrogen-, oxygen-, and sulfur-containing heteroaryl boronic acids were achieved in high yields with only 0.5 mol % of the single-component nickel precatalyst [(dppf)NiCl(cinnamyl)] (dppf=1,1′-bis(diphenylphosphanyl)ferrocene). The reaction demonstrates good functional group compatibility, and is easily conducted on a large scale without a dry box.