Synthesis of ortho-Acylphenols through the Palladium-Catalyzed Ketone-Directed Hydroxylation of Arenes

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Errata

This article is corrected by:

  1. Errata: Corrigendum: Synthesis of ortho-Acylphenols through the Palladium-Catalyzed Ketone-Directed Hydroxylation of Arenes Volume 52, Issue 21, 5425, Article first published online: 10 May 2013

  • We thank UT Austin and CPRIT for a start-up fund, and thank the Welch Foundation and the Frasch Foundation for research grants. G.D. thanks ORAU for a new faculty enhancement award. We also thank faculty members from the organic division at UT Austin for their generous support. Dr. Lynch is acknowledged for X-ray crystallography. We thank Dr. Shoulders, Mrs. Spangenberg, and Mr. Sorey for their NMR advice.

Abstract

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Ketone in charge: A formal ketone-directed palladium-catalyzed ortho-hydroxylation of arenes has been developed as an effective approach to access o-acylphenols from simple arylketones. A Pd-catalyzed oxidative ortho-carbonylation reaction using ketone directing groups to access a ketal–lactone motif is also demonstrated. The ubiquity and versatile nature of ketones make these methods attractive. BTI=PhI(TFA)2; DCE=1,2-dichloroethane.

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