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Using Thermally Regenerable Cerium Oxide Nanoparticles in Biocomputing to Perform Label-free, Resettable, and Colorimetric Logic Operations

Authors

  • Youhui Lin,

    1. State Key laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (China)
    2. Graduate School of the Chinese Academy of Sciences, Beijing 100039 (China)
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  • Can Xu,

    1. State Key laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (China)
    2. Graduate School of the Chinese Academy of Sciences, Beijing 100039 (China)
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  • Prof. Dr. Jinsong Ren,

    Corresponding author
    1. State Key laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (China)
    2. Graduate School of the Chinese Academy of Sciences, Beijing 100039 (China)
    • State Key laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (China)
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  • Prof. Dr. Xiaogang Qu

    Corresponding author
    1. State Key laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (China)
    2. Graduate School of the Chinese Academy of Sciences, Beijing 100039 (China)
    • State Key laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022 (China)
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  • Financial support was provided by the National Basic Research Program of China (2011CB936004 and 2012CB720602) and the National Natural Science Foundation of China (20831003, 21210002, 20833006, 90913007, 21072182).

Abstract

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A label-free, resettable, and colorimetric logic network has been realized by utilizing thermally regenerable cerium oxide nanoparticles and biocatalytic reactions. Coupling switchable CeO2 nanoparticles with biocomputing would convert molecular recognition events into colorimetric outputs and make logic gates feasible to reset.

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