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Keywords:

  • cell recognition;
  • cooperative phenomena;
  • multivalency;
  • receptors;
  • supramolecular chemistry
Thumbnail image of graphical abstract

Multivalent binding of dendritic polyglycerolsulfate (dPGS) to the surface-exposed adhesion receptor L-selectin shields white blood cells from contacting activated vascular endothelium. In the case of overwhelming inflammation, dPGS treatment strongly inhibits leukocyte emigration and thus acts as a highly effective anti-inflammatory compound. Further information on the topic of multivalency can be found in the Review by R. Haag et al. on page 10472 ff. The cover picture was designed by Dipl.-Chem. Achim Wiedekind, with the background based on a graphic from Juan Gaertner/shutterstock.com.