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Communication

Asbestos-like Pathogenicity of Long Carbon Nanotubes Alleviated by Chemical Functionalization†

  1. Dr. Hanene Ali-Boucetta1,5,
  2. Dr. Antonio Nunes1,
  3. Dr. Raquel Sainz2,6,
  4. Dr.  M. Antonia Herrero4,
  5. Dr. Bowen Tian1,
  6. Prof. Maurizio Prato3,*,
  7. Dr. Alberto Bianco2,*,
  8. Prof. Kostas Kostarelos1,*

Article first published online: 14 JAN 2013

DOI: 10.1002/anie.201207664

Issue

Angewandte Chemie International Edition

Angewandte Chemie International Edition

Volume 52, Issue 8, pages 2274–2278, February 18, 2013

Additional Information

How to Cite

Ali-Boucetta, H., Nunes, A., Sainz, R., Herrero, M. A., Tian, B., Prato, M., Bianco, A. and Kostarelos, K. (2013), Asbestos-like Pathogenicity of Long Carbon Nanotubes Alleviated by Chemical Functionalization . Angew. Chem. Int. Ed., 52: 2274–2278. doi: 10.1002/anie.201207664

Author Information

  1. 1

    Nanomedicine Laboratory, UCL School of Pharmacy, University College London, Brunswick Square, London WC1N 1AX (UK)

  2. 2

    CNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d'Immunopathologie et Chimie Thérapeutique, 67000 Strasbourg (France)

  3. 3

    Dipartimento di Scienze Farmaceutiche, Università di Trieste, 34127 Trieste (Italy)

  4. 4

    Departamento de Química Orgánica, Facultad de Química, Universidad de Castilla-La Mancha, 13071 Ciudad Real (Spain)

  5. 5

    Current address: Pharmacy, Pharmacology and Therapeutics, School of Experimental and Clinical Medicine, Medical School, University of Birmingham, Birmingham B15 2TT (UK)

  6. 6

    Current address: NanoInnova Technologies SL, Parque Científico de Madrid, Madrid (Spain)

*Dipartimento di Scienze Farmaceutiche, Università di Trieste, 34127 Trieste (Italy)

  1. †

    Part of the work described in this article was supported by the European Union FP7 ANTICARB program (HEALTH-2007-201587) and ERC Advanced Grant Carbonanobridge (ERC-2008-AdG-227135). We wish to thank the Centre National de la Recherche Scientifique (CNRS), the University of Trieste, the Italian Ministry of Education MIUR (Cofin Prot. 20085M27SS and FIRB prot. RBAP11ETKA), Regione Friuli-Venezia Giulia (Nanocancer), and AIRC (AIRC 5 per mille, Rif. 12214 “Application of Advanced Nanotechnology in the Development of Innovative Cancer Diagnostics Tools”). H.A.-B. was a recipient of the postdoctoral Maplethorpe Fellowship from the University of London. R.S. wishes to acknowledge FP6 European Union program NEURONANO (NMP4-CT-2006-031847). We would like to acknowledge Prof. K. Donaldson and Dr. C. Poland at the MRC/University of Edinburgh Centre for Inflammation Research for their advice, critical reading of this manuscript, and the provision of the long, pristine MWNTs (NTlong). The reductively functionalized MWNTs (NT-Alkyl) were provided by Dr. A. Higginbotham-Duque and Prof. J. Tour at Rice University, Texas (USA). Prof. J. Tour is also acknowledged for critically reading this manuscript.

Publication History

  1. Issue published online: 13 FEB 2013
  2. Article first published online: 14 JAN 2013
  3. Manuscript Revised: 27 NOV 2012
  4. Manuscript Received: 22 SEP 2012

Funded by

  • European Union. Grant Number: HEALTH-2007-201587
  • ERC Advanced Grant Carbonanobridge. Grant Number: ERC-2008-AdG-227135
  • Centre National de la Recherche Scientifique (CNRS)
  • University of Trieste
  • Italian Ministry of Education MIUR. Grant Number: 20085M27SS
  • Regione Friuli-Venezia Giulia
  • AIRC
  • European Union. Grant Number: NMP4-CT-2006-031847

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Keywords:

  • graphene;
  • carcinogenicity;
  • inflammation;
  • nanoparticles;
  • toxicology
Thumbnail image of graphical abstract

Sometimes shorter is better: The apparent similarity between multi-walled carbon nanotubes (MWNTs) and asbestos fibers has generated serious concerns about their safety profile. The asbestos-like pathogenicity observed for long, pristine nanotubes (NTlong, see scheme) can be completely alleviated if their effective length is decreased as a result of chemical functionalization, such as with tri(ethylene glycol) (TEG).

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