SEARCH

SEARCH BY CITATION

Keywords:

  • helical structure;
  • nanotubes;
  • peptides;
  • self-assembly;
  • X-ray diffraction
Thumbnail image of graphical abstract

Elaborate morphology: The αSβ1 peptide, a fragment of α-synuclein, assembles into flat tapes consisting of a peptide bilayer, which can be modeled based on the cross-β structure found in amyloid proteins. The tapes are stabilized by hydrogen bonding, whilst the amphiphilic nature of the peptide results in the thin bilayer structure. To further stabilize the structure, these tapes may twist to form helical tapes, which subsequently close into nanotubes.