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Rhodium-Catalyzed Asymmetric Synthesis of Spirosilabifluorene Derivatives

Authors

  • Prof. Dr. Yoichiro Kuninobu,

    Corresponding author
    1. Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushimanaka, Kita-ku, Okayama 700-8530 (Japan)
    2. Present Address: Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan)
    • Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushimanaka, Kita-ku, Okayama 700-8530 (Japan)
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  • Kanae Yamauchi,

    1. Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushimanaka, Kita-ku, Okayama 700-8530 (Japan)
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  • Naoya Tamura,

    1. Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushimanaka, Kita-ku, Okayama 700-8530 (Japan)
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  • Takayuki Seiki,

    1. Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushimanaka, Kita-ku, Okayama 700-8530 (Japan)
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  • Prof. Dr. Kazuhiko Takai

    Corresponding author
    1. Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushimanaka, Kita-ku, Okayama 700-8530 (Japan)
    • Division of Chemistry and Biotechnology, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushimanaka, Kita-ku, Okayama 700-8530 (Japan)
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Errata

This article is corrected by:

  1. Errata: Corrigendum: Rhodium-Catalyzed Asymmetric Synthesis of Spirosilabifluorene Derivatives Volume 55, Issue 6, 1948, Article first published online: 2 February 2016

  • This work was partially supported by the Ministry of Education, Culture, Sports, Science, and Technology of Japan.

Abstract

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Si goes chiral: Treatment of a bis(biphenyl)silane with a catalytic amount of a rhodium complex gave a spirosilabifluorene bearing a quaternary silicon atom. By using a rhodium catalyst with a chiral phosphine ligand (see scheme), asymmetric dehydrogenative cyclization proceeded to give chiral derivatives in good yields and enantioselectivities.

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