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Keywords:

  • amino acids;
  • chirality;
  • NMR spectroscopy;
  • peptides;
  • reactive intermediates
Thumbnail image of graphical abstract

The early days: Although considered a species to be avoided in peptide chemistry, the intermediacy of 5(4H)-oxazolones is demonstrated to be essential for the formation of peptides through cyanamide and carbodiimide activation in aqueous solution (see scheme).