Back Cover: A Phenylboronate-Functionalized Polyion Complex Micelle for ATP-Triggered Release of siRNA (Angew. Chem. Int. Ed. 43/2012)

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Abstract

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Delivery of small interfering RNA is described by K. Kataoka et al. in their Communication on page 10751 ff. siRNA encapsulated in a phenylboronate-functionalized polyion complex micelle shows specific binding between the pendent phenylboronate and the 3′-ribose moiety of the siRNA, stabilizing the complex under extracellular conditions. This complex is disrupted upon addition of ATP at a concentration comparable to that inside cells.

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