We thank the EPSRC and Pfizer for funding under both the collaborative EPSRC Programme for Synthetic Organic Chemistry with AZ-GSK-Pfizer (E.C.N.) and for funding from Bristol Chemical Synthesis Doctoral Training Centre (PMC) and the EPSRC for student (J.N.) and postdoctoral (EC) support.
Simplifying Iron–Phosphine Catalysts for Cross-Coupling Reactions†
Article first published online: 6 DEC 2012
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 4, pages 1285–1288, January 21, 2013
How to Cite
Bedford, R. B., Carter, E., Cogswell, P. M., Gower, N. J., Haddow, M. F., Harvey, J. N., Murphy, D. M., Neeve, E. C. and Nunn, J. (2013), Simplifying Iron–Phosphine Catalysts for Cross-Coupling Reactions . Angew. Chem. Int. Ed., 52: 1285–1288. doi: 10.1002/anie.201207868
- Issue published online: 15 JAN 2013
- Article first published online: 6 DEC 2012
- Manuscript Revised: 26 OCT 2012
- Manuscript Received: 28 SEP 2012
- Bristol Chemical Synthesis Doctoral Training Centre
- alkyl halides;
- phosphine ligands
Any old iron? Iron catalysts based on the widely available diphosphine ligand bis(diphenylphosphino)ethane have not previously fared particularly well in iron-catalyzed cross-coupling processes. However, this turns out not to be due to any inherently poor performance associated with the ligand, but rather the need to form a bis-chelate complex, either before or during the formation of an active FeI species.