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Simplifying Iron–Phosphine Catalysts for Cross-Coupling Reactions


  • We thank the EPSRC and Pfizer for funding under both the collaborative EPSRC Programme for Synthetic Organic Chemistry with AZ-GSK-Pfizer (E.C.N.) and for funding from Bristol Chemical Synthesis Doctoral Training Centre (PMC) and the EPSRC for student (J.N.) and postdoctoral (EC) support.


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Any old iron? Iron catalysts based on the widely available diphosphine ligand bis(diphenylphosphino)ethane have not previously fared particularly well in iron-catalyzed cross-coupling processes. However, this turns out not to be due to any inherently poor performance associated with the ligand, but rather the need to form a bis-chelate complex, either before or during the formation of an active FeI species.