Multifunctional Gold Nanorods with Ultrahigh Stability and Tunability for In Vivo Fluorescence Imaging, SERS Detection, and Photodynamic Therapy

Authors

  • Yuan Zhang,

    1. Centre for Optical and Electromagnetic Research, Zhejiang Provincial Key Laboratory for Sensing Technologies, JORCEP [Joint Research Center of Photonics of the Royal Institute of Technology (Sweden), Lund University (Sweden), and Zhejiang University], Zhejiang University, Hangzhou, 310058 (China)
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  • Dr. Jun Qian,

    1. Centre for Optical and Electromagnetic Research, Zhejiang Provincial Key Laboratory for Sensing Technologies, JORCEP [Joint Research Center of Photonics of the Royal Institute of Technology (Sweden), Lund University (Sweden), and Zhejiang University], Zhejiang University, Hangzhou, 310058 (China)
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  • Dan Wang,

    1. Centre for Optical and Electromagnetic Research, Zhejiang Provincial Key Laboratory for Sensing Technologies, JORCEP [Joint Research Center of Photonics of the Royal Institute of Technology (Sweden), Lund University (Sweden), and Zhejiang University], Zhejiang University, Hangzhou, 310058 (China)
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  • Yalun Wang,

    1. Centre for Optical and Electromagnetic Research, Zhejiang Provincial Key Laboratory for Sensing Technologies, JORCEP [Joint Research Center of Photonics of the Royal Institute of Technology (Sweden), Lund University (Sweden), and Zhejiang University], Zhejiang University, Hangzhou, 310058 (China)
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  • Prof. Sailing He

    Corresponding author
    1. Centre for Optical and Electromagnetic Research, Zhejiang Provincial Key Laboratory for Sensing Technologies, JORCEP [Joint Research Center of Photonics of the Royal Institute of Technology (Sweden), Lund University (Sweden), and Zhejiang University], Zhejiang University, Hangzhou, 310058 (China)
    • Centre for Optical and Electromagnetic Research, Zhejiang Provincial Key Laboratory for Sensing Technologies, JORCEP [Joint Research Center of Photonics of the Royal Institute of Technology (Sweden), Lund University (Sweden), and Zhejiang University], Zhejiang University, Hangzhou, 310058 (China)
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  • This work was partially supported by the Science and Technology Department of Zhejiang Province, the National Basic Research Program (973) of China (2011CB503700), the National Natural Science Foundation of China (61008052 and 61108022), and the Fundamental Research Funds for the Central Universities. SERS=surface-enhanced Raman scattering.

Abstract

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Multimodal: Gold nanorods are coated with silica/polymer mutilayers, doped with surface-enhance Raman scattering (SERS) and fluorescence agents as well as photosensitizers. The structural and optical properties are tunable and stable in solutions and in living bodies. A real-time and specific in vivo SERS and fluorescence detection method using this structure is applied for tumor detection and subsequent photodynamic therapy (PDT).

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