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Photolithographic Boronate Affinity Molecular Imprinting: A General and Facile Approach for Glycoprotein Imprinting

Authors

  • Li Li,

    1. State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 22 Hankou Road, Nanjing 210093 (China)
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  • Yue Lu,

    1. State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 22 Hankou Road, Nanjing 210093 (China)
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  • Zijun Bie,

    1. State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 22 Hankou Road, Nanjing 210093 (China)
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  • Prof. Hong-Yuan Chen,

    1. State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 22 Hankou Road, Nanjing 210093 (China)
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  • Dr. Zhen Liu

    Corresponding author
    1. State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 22 Hankou Road, Nanjing 210093 (China)
    • State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 22 Hankou Road, Nanjing 210093 (China)
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  • We gratefully acknowledge the financial support from the Ministry of Science and Technology of China (Grant Nos. 2013CB911202 and 2008DFA01910), the National Natural Science Foundation of China (Grant Nos. 21075063, 21275073, and 21121091), and the Natural Science Foundation of Jiangsu Province, China (Grant No. KB2011054).

Abstract

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Better than expected: With a regular boronic acid as the functional monomer, a general and facile approach for glycoprotein imprinting exhibited several highly favorable features that are beyond normal expectation, which make the prepared MIPs feasible for the recognition of trace glycoproteins in complicated real samples.

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