SEARCH

SEARCH BY CITATION

Keywords:

  • cross-coupling;
  • kinetics;
  • reaction mechanisms;
  • synergistic catalysis;
  • transmetalation
Thumbnail image of graphical abstract

Rate-limiting: The transmetalation step of the Sonogashira coupling reaction has been established as the rate-limiting step. This cross-coupling has been demonstrated to be a Pd-catalyzed and Cu-catalyzed synergistic process, which exhibits a first-order kinetic dependence on both the [Pd] and [Cu] catalysts (see scheme).