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Photothermally Activated Hybrid Films for Quantitative Confined Release of Chemical Species

Authors

  • Dr. Paolo Matteini,

    Corresponding author
    1. Institute of Applied Physics “Nello Carrara”, National Research Council via Madonna del Piano 10, 50019 (Italy)
    • Institute of Applied Physics “Nello Carrara”, National Research Council via Madonna del Piano 10, 50019 (Italy)

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  • Dr. Francesca Tatini,

    1. Institute of Applied Physics “Nello Carrara”, National Research Council via Madonna del Piano 10, 50019 (Italy)
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  • Dr. Lapo Luconi,

    1. Institute of Chemistry of Organometallic Compounds, National Research Council via Madonna del Piano 10, 50019 (Italy)
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  • Dr. Fulvio Ratto,

    1. Institute of Applied Physics “Nello Carrara”, National Research Council via Madonna del Piano 10, 50019 (Italy)
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  • Dr. Francesca Rossi,

    1. Institute of Applied Physics “Nello Carrara”, National Research Council via Madonna del Piano 10, 50019 (Italy)
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  • Dr. Giuliano Giambastiani,

    1. Institute of Chemistry of Organometallic Compounds, National Research Council via Madonna del Piano 10, 50019 (Italy)
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  • Prof. Roberto Pini

    Corresponding author
    1. Institute of Applied Physics “Nello Carrara”, National Research Council via Madonna del Piano 10, 50019 (Italy)
    • Institute of Applied Physics “Nello Carrara”, National Research Council via Madonna del Piano 10, 50019 (Italy)

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  • This work has been partially supported by the Project of the Health Board of the Tuscan Region “NANO-CHROM” and “IPERNANO” and by the Network of Excellence “Photonics 4 Life”.

Abstract

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Illuminating films of a porous chitosan matrix containing gold nanorods and thermosensitive micelles loaded with a chemical stimulates local photothermal conversion of the gold nanorods. The heat produced activates the ejection of the chemical from the micelles (see scheme), and causes the transient permeabilization of adjacent cell membranes, resulting in a selective cellular uptake of the released chemical with control over spatiotemporal parameters and dosage.

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