This research was supported by the EU (METACHEM, grant number CP-FP 228762-2), the Spanish Ministerio de Economía y Competitividad (MAT2010-15374), Fundación Ramón Areces and the DFG (PA794/11-1 to W.J.P.).
Physicochemical Properties of Protein-Coated Gold Nanoparticles in Biological Fluids and Cells before and after Proteolytic Digestion†
Article first published online: 7 MAR 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 15, pages 4179–4183, April 8, 2013
How to Cite
Chanana, M., Rivera_Gil, P., Correa-Duarte, M. A., Liz-Marzán, L. M. and Parak, W. J. (2013), Physicochemical Properties of Protein-Coated Gold Nanoparticles in Biological Fluids and Cells before and after Proteolytic Digestion . Angew. Chem. Int. Ed., 52: 4179–4183. doi: 10.1002/anie.201208019
- Issue published online: 3 APR 2013
- Article first published online: 7 MAR 2013
- Manuscript Revised: 4 FEB 2013
- Manuscript Received: 4 OCT 2012
- drug delivery;
- protein-coated nanoparticles;
What's going on in there?! Little is known about the fate of nanoparticles (NPs) after their internalization by cells and organisms. Protein-coated gold NPs were used to study the physicochemical properties of NPs in extra- and intracellular fluids. These potential vehicles for enzymatic drug delivery were highly stable at pH 7.4 in the presence of salts and free proteins, but agglomerated reversibly under acidic conditions (see picture).