SEARCH

SEARCH BY CITATION

Keywords:

  • aldehydes;
  • cross-coupling;
  • nitrogen heterocycles;
  • radical reactions;
  • thiomorpholines
Thumbnail image of graphical abstract

It's a SnAP! The transformation of aldehydes into N-unsubstituted 3-thiomorpholines provides a convenient alternative to metal-catalyzed cross-coupling reactions, which are generally unsuited to the functionalization of saturated N-heterocycles. A copper-mediated radical cyclization is the key to the mild conditions, high functional group tolerance, and broad substrate scope offered by these reagents.