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Palladium-Catalyzed Oxidative Cycloaddition through C[BOND]H/N[BOND]H Activation: Access to Benzazepines

Authors

  • Lei Wang,

    1. Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543 (Singapore)
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  • Jiayao Huang,

    1. Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543 (Singapore)
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  • Shiyong Peng,

    1. Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543 (Singapore)
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  • Dr. Hui Liu,

    1. Shanghai Key Laboratory of Green Chemistry and Chemical Process, East China Normal University, 3663N, Zhongshan Road, Shanghai, 200062 (China)
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  • Prof. Dr. Xuefeng Jiang,

    Corresponding author
    1. Shanghai Key Laboratory of Green Chemistry and Chemical Process, East China Normal University, 3663N, Zhongshan Road, Shanghai, 200062 (China)
    • Shanghai Key Laboratory of Green Chemistry and Chemical Process, East China Normal University, 3663N, Zhongshan Road, Shanghai, 200062 (China)
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  • Prof. Dr. Jian Wang

    Corresponding author
    1. Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543 (Singapore)
    • Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543 (Singapore)
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  • Financial support from Singapore through the National University of Singapore, the Singapore Ministry of Education, and the National Research Foundation (R14300080112, R143000443112, and NRF-CRP7-2010-03), as well as from China through an NSFC grant (21272075) is greatly appreciated.

Abstract

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Rings beget rings: Benzazepines, well-known structural design elements in medicinal chemistry, are readily prepared by a one-pot palladium-catalyzed oxidative cycloaddition of isatins with various alkynes.

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