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Systemic Delivery of microRNA-34a for Cancer Stem Cell Therapy

Authors

  • Sanjun Shi,

    1. Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University Chengdu, No.17, Section 3, Renmin South Rd, Chengdu, 610041 (P.R. China)
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  • Lu Han,

    1. Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University Chengdu, No.17, Section 3, Renmin South Rd, Chengdu, 610041 (P.R. China)
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  • Prof. Tao Gong,

    1. Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University Chengdu, No.17, Section 3, Renmin South Rd, Chengdu, 610041 (P.R. China)
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  • Prof. Zhirong Zhang,

    1. Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University Chengdu, No.17, Section 3, Renmin South Rd, Chengdu, 610041 (P.R. China)
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  • Prof. Xun Sun

    Corresponding author
    1. Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University Chengdu, No.17, Section 3, Renmin South Rd, Chengdu, 610041 (P.R. China)
    • Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University Chengdu, No.17, Section 3, Renmin South Rd, Chengdu, 610041 (P.R. China)
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  • We thank the National Science Foundation of China (No. 81130060), the Program for New Century Excellent Talents in University (No. NTEC-10-0601), and the National Science & Technology Major Project of China (No. 2011ZX09401-304(4-3)) for financial support. We also thank Dr. Chester Provoda from the University of Michigan for his help in preparing this manuscript.

Abstract

original image

Delivered: A solid lipid nanoparticle (SLN) system was developed to deliver microRNA-34a (miR-34a) relevant for cancer stem cell (CSC) therapy into lung tissues. In miR-34a-containing SLNs (miSLNs-34a), miR-34a is protected from degradation in the serum and its cellular-transfection efficiency in vitro is increased. Thus, treatment with miSLNs-34a results in a higher probability of survival of CSC-bearing mice (see picture).

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