Stable Aqueous Dispersions of Glycopeptide-Grafted Selectably Functionalized Magnetic Nanoparticles

Authors


  • T.N., C.K., and D.B. acknowledge support from Enterprise Ireland (TD20080135). S.R. acknowledges the DCU Targeted Research Initiative Fund (TRIF). A.H. and T.B. acknowledge Science Foundation Ireland for a Principle Investigator Award (07/IN1/B1792). A.K. acknowledges the IUPAC glycopeptides project (AC-POL-09-11-25). A.H. is a SFI Stokes Senior Lecturer (07/SK/B1241). We thank Dr. Cormac O’Connell, Electron Microscopy Laboratory, University College Dublin, for access to TEM facilities.

Abstract

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Sweet nanomagnets: Suspensions of glycopeptide grafted magnetic nanoparticles can be produced by N-carboxyanhydride ring-opening polymerization with subsequent click glycosylation. The resulting materials have a high sugar density, optimal dispersion and T1-weighted MRI properties, and bio-recognition ability. The approach can be used to attach any type or combination of functional groups, the density of which is not limited by particle surface area.

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