Catalytic Stereoselective Semihydrogenation of Alkynes to E-Alkenes

Authors

  • Iacovos N. Michaelides,

    1. Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA (UK)
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  • Prof. Dr. Darren J. Dixon

    Corresponding author
    1. Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA (UK)
    • Chemistry Research Laboratory, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA (UK)
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  • We thank the EPSRC (leadership fellowship to D.J.D. and studentship to I.N.M.) and Syngenta (studentship to I.N.M.) for financial support.

Abstract

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Less is more: Significant advancements have been made in recent years in the development of the E-selective, catalytic, functional-group-tolerant semihydrogenation of alkynes to E-alkenes through transition-metal catalysis (see scheme). For this type of catalysis, the use of mononuclear metal catalysts is superior to that of multinuclear metal catalysts.

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