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New Insights into Gene Regulation—High-Resolution Structures of Cobalamin Riboswitches

Authors

  • Dr. Marie F. Soulière,

    1. Institute of Organic Chemistry (IOC) and Center for Molecular Biosciences (CMBI), University of Innsbruck, Center for Chemistry and Biomedicine (CCB), 6020 Innsbruck (Austria)
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  • Mag. Andrea Haller,

    1. Institute of Organic Chemistry (IOC) and Center for Molecular Biosciences (CMBI), University of Innsbruck, Center for Chemistry and Biomedicine (CCB), 6020 Innsbruck (Austria)
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  • Mag. Tobias Santner,

    1. Institute of Organic Chemistry (IOC) and Center for Molecular Biosciences (CMBI), University of Innsbruck, Center for Chemistry and Biomedicine (CCB), 6020 Innsbruck (Austria)
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  • Prof. Dr. Ronald Micura

    Corresponding author
    1. Institute of Organic Chemistry (IOC) and Center for Molecular Biosciences (CMBI), University of Innsbruck, Center for Chemistry and Biomedicine (CCB), 6020 Innsbruck (Austria)
    • Institute of Organic Chemistry (IOC) and Center for Molecular Biosciences (CMBI), University of Innsbruck, Center for Chemistry and Biomedicine (CCB), 6020 Innsbruck (Austria)
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  • We thank Robert T. Batey (University of Boulder) and Alexander Serganov (NYULMC) for providing their manuscripts and pdb files prior to publication.

Abstract

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The complex class of cobalamin-sensitive riboswitches use a “kissing loop” to regulate gene expression. The molecular details of the recognition and folding mode of this riboswitch have been revealed by recent X-ray structures. These insights, together with the identification of RNA polymerase pause sites during transcription, have resulted in a more complete understanding of the response mechanism. AdoCbl=adenosylcobalamin.

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