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Elucidating the Biosynthetic Pathway for Vibralactone: A Pancreatic Lipase Inhibitor with a Fused Bicyclic β-Lactone

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  • This research was supported by grants from the National Natural Science Foundation of China (31170061), and the National Basic Research Program of China (973 program, 2009CB522300 and 2013CB127500). We are grateful to Wolfgang Eisenreich (Technical University of Munich (Germany)), Zi-Hua Justin Jiang (Lakehead University, Canada) and anonymous reviewers for their comments.

Abstract

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Not so simple: Evidence from 13C-labeling studies, metabolite profiling, and cell-free conversion established that the bicycle skeleton of vibralactone is derived from an aryl ring moiety and both shikimate and phenylalanine pathways may contribute. VibPT was found to be potentially involved in vibralactone biosynthesis, as well as an aromatic PTase, which was first characterized in basidiomycete fungi. OPP=pyrophosphate.

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