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Keywords:

  • (+)-virosaine B;
  • (−)-flueggine A;
  • asymmetric synthesis;
  • natural products;
  • total synthesis
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Convergent approach: The total syntheses of (−)-flueggine A and (+)-virosaine B (see scheme) have been accomplished in a concise and convergent manner. Key steps in these approaches were relay ring-closing metathesis reactions for rapid construction of the key intermediates, and 1,3-dipolar cycloaddition reactions for the formation of the natural products.