Hydrodynamically Driven Self-Assembly of Giant Vesicles of Metal Nanoparticles for Remote-Controlled Release

Authors

  • Dr. Jie He,

    1. Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742 (USA)
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  • Zengjiang Wei,

    1. Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742 (USA)
    2. Research Institute of Materials Science, South China University of Technology, Guangzhou 510640 (China)
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  • Lei Wang,

    1. Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742 (USA)
    2. School of Chemical Engineering and Technology, Harbin Institute of Technology, Harbin 150001 (China)
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  • Zuleykhan Tomova,

    1. Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742 (USA)
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  • Taarika Babu,

    1. Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742 (USA)
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  • Prof. Dr. Chaoyang Wang,

    1. Research Institute of Materials Science, South China University of Technology, Guangzhou 510640 (China)
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  • Prof. Dr. Xiaojun Han,

    1. School of Chemical Engineering and Technology, Harbin Institute of Technology, Harbin 150001 (China)
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  • Prof. Dr. John T. Fourkas,

    1. Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742 (USA)
    2. Institute for Physical Science and Technology, University of Maryland, College Park, MD 20742 (USA)
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  • Prof. Dr. Zhihong Nie

    Corresponding author
    1. Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742 (USA)
    • Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742 (USA)
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  • This work is supported by startup funds and the Research and Scholarship Award from the University of Maryland. We thank Dr. Wen-An Chiou for help with Cryo-TEM imaging. T.B. thanks the support of Arnold and Mabel Beckman Foundation. Z.W. thanks the support of the China Scholarship Council. We also acknowledge the support of the Maryland NanoCenter and its NispLab and FabLab. The NispLab is supported in part by the NSF as a MRSEC Shared Experimental Facilities.

Abstract

original image

The hydrodynamics of laminar flow in a microfluidic device has been used to control the continuous self-assembly of gold nanoparticles (NPs) tethered with amphiphilic block copolymers. Spherical micelles, giant vesicles (500 nm–2.0 μm), or disk-like micelles could be formed by varying the flow rates of fluids. Such vesicles can release encapsulated hydrophilic species by using near-IR light (see picture).

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