An Air-Stable Copper Reagent for Nucleophilic Trifluoromethylthiolation of Aryl Halides

Authors

  • Prof. Dr. Zhiqiang Weng,

    Corresponding author
    1. Department of Chemistry and Fujian Provincial Key Laboratory of Photocatalysis—State Key Laboratory Breeding Base, Fuzhou University, Fuzhou 350002 (China)
    • Department of Chemistry and Fujian Provincial Key Laboratory of Photocatalysis—State Key Laboratory Breeding Base, Fuzhou University, Fuzhou 350002 (China)
    Search for more papers by this author
  • Weiming He,

    1. Department of Chemistry and Fujian Provincial Key Laboratory of Photocatalysis—State Key Laboratory Breeding Base, Fuzhou University, Fuzhou 350002 (China)
    Search for more papers by this author
  • Chaohuang Chen,

    1. Department of Chemistry and Fujian Provincial Key Laboratory of Photocatalysis—State Key Laboratory Breeding Base, Fuzhou University, Fuzhou 350002 (China)
    Search for more papers by this author
  • Richmond Lee,

    1. Division of Physical Science and Engineering, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900 (Saudi Arabia)
    Search for more papers by this author
  • Davin Tan,

    1. Division of Physical Science and Engineering, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900 (Saudi Arabia)
    Search for more papers by this author
  • Prof. Dr. Zhiping Lai,

    1. Division of Physical Science and Engineering, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900 (Saudi Arabia)
    Search for more papers by this author
  • Dedao Kong,

    1. Department of Chemistry and Fujian Provincial Key Laboratory of Photocatalysis—State Key Laboratory Breeding Base, Fuzhou University, Fuzhou 350002 (China)
    Search for more papers by this author
  • Prof. Dr. Yaofeng Yuan,

    1. Department of Chemistry and Fujian Provincial Key Laboratory of Photocatalysis—State Key Laboratory Breeding Base, Fuzhou University, Fuzhou 350002 (China)
    Search for more papers by this author
  • Prof. Dr. Kuo-Wei Huang

    Corresponding author
    1. Division of Physical Science and Engineering, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900 (Saudi Arabia)
    • Division of Physical Science and Engineering, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900 (Saudi Arabia)
    Search for more papers by this author

  • We thank Prof. John Hartwig for useful discussions. The financial support from National Natural Science Foundation of China (21072030) and Fuzhou University (022318) to Z.W. and KAUST to K.-W.H. are acknowledged.

Abstract

original image

A series of copper(I) trifluoromethyl thiolate complexes have been synthesized from the reaction of CuF2 with Me3SiCF3 and S8 (see scheme; Cu red, F green, N blue, S yellow). These air-stable complexes serve as reagents for the efficient conversion of a wide range of aryl halides into the corresponding aryl trifluoromethyl thioethers in excellent yields.

Ancillary