Reactions Templated by Nucleic Acids: More Ways to Translate Oligonucleotide-Based Instructions into Emerging Function

Authors

  • Dr. Katarzyna Gorska,

    1. Institut de Science et Ingénierie Supramoléculaires (ISIS—UMR 7006), Universite de Strasbourg—CNRS, 8 allée Gaspard Monge, 67000 Strasbourg (France)
    2. Department of Organic Chemistry, University of Geneva (Switzerland)
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  • Prof. Nicolas Winssinger

    Corresponding author
    1. Institut de Science et Ingénierie Supramoléculaires (ISIS—UMR 7006), Universite de Strasbourg—CNRS, 8 allée Gaspard Monge, 67000 Strasbourg (France)
    2. Department of Organic Chemistry, University of Geneva (Switzerland)
    • Institut de Science et Ingénierie Supramoléculaires (ISIS—UMR 7006), Universite de Strasbourg—CNRS, 8 allée Gaspard Monge, 67000 Strasbourg (France)

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Abstract

The programmability of oligonucleotide recognition offers an attractive platform to direct the assembly of reactive partners that can engage in chemical reactions. Recently, significant progress has been made in both the breadth of chemical transformations and in the functional output of the reaction. Herein we summarize these recent progresses and illustrate their applications to translate oligonucleotide instructions into functional materials and novel architectures (conductive polymers, nanopatterns, novel oligonucleotide junctions); into fluorescent or bioactive molecule using cellular RNA; to interrogate secondary structures or oligonucelic acids; or a synthetic oligomer.

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