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Keywords:

  • cystic fibrosis;
  • DNA nanoparticles;
  • gene therapy;
  • mucus-penetrating particles;
  • nanotechnology
Thumbnail image of graphical abstract

Mucus-penetrating DNA nanoparticles: A novel synthetic strategy was used to achieve a dense PEG coating on the surface of cationic polymer-based DNA nanoparticles. The dense PEG coating (blue in scheme) endows the nanoparticles with a muco-inert surface, which enables their rapid mucus penetration (trajectory indicated by gray line) and provides efficient gene transfer in various cell types.