The work was supported by a grant from the NIH-NIGMS (RO1 086374), the NSF-USA (graduate fellowship to J.N.N.) and DAAD (postdoctoral fellowship to D.F.F.).
Synthetic Studies on Pseudo-Dimeric Lycopodium Alkaloids: Total Synthesis of Complanadine B†
Article first published online: 10 JAN 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 6, pages 1726–1730, February 4, 2013
How to Cite
Newton, J. N., Fischer, D. F. and Sarpong, R. (2013), Synthetic Studies on Pseudo-Dimeric Lycopodium Alkaloids: Total Synthesis of Complanadine B . Angew. Chem. Int. Ed., 52: 1726–1730. doi: 10.1002/anie.201208571
- Issue published online: 1 FEB 2013
- Article first published online: 10 JAN 2013
- Manuscript Received: 24 OCT 2012
- NIH-NIGMS. Grant Number: RO1 086374
- borylative C-H functionalization;
- pyridine oxidation;
- total synthesis
Two approaches to the total synthesis of the dimeric Lycopodium alkaloid complanadine B have been achieved. In the first approach (see scheme; route 1), a keto lycodine unit is coupled to another lycodine unit whereas in the latter approach (route 2), selective oxygenation of one of two pseudo-benzylic positions is achieved.