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Keywords:

  • alkaloids;
  • borylative C-H functionalization;
  • complanadine;
  • pyridine oxidation;
  • total synthesis
Thumbnail image of graphical abstract

Two approaches to the total synthesis of the dimeric Lycopodium alkaloid complanadine B have been achieved. In the first approach (see scheme; route 1), a keto lycodine unit is coupled to another lycodine unit whereas in the latter approach (route 2), selective oxygenation of one of two pseudo-benzylic positions is achieved.