Synthetic Studies on Pseudo-Dimeric Lycopodium Alkaloids: Total Synthesis of Complanadine B


  • The work was supported by a grant from the NIH-NIGMS (RO1 086374), the NSF-USA (graduate fellowship to J.N.N.) and DAAD (postdoctoral fellowship to D.F.F.).


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Two approaches to the total synthesis of the dimeric Lycopodium alkaloid complanadine B have been achieved. In the first approach (see scheme; route 1), a keto lycodine unit is coupled to another lycodine unit whereas in the latter approach (route 2), selective oxygenation of one of two pseudo-benzylic positions is achieved.