Carboxy-Directed Asymmetric Hydrogenation of 1,1-Diarylethenes and 1,1-Dialkylethenes

Authors


  • We thank the National Natural Science Foundation of China, the National Basic Research Program of China (2011CB808600), and the Ministry of Education of China (B06005) for financial support.

Abstract

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Carboxy marks the spot: A carboxy-directed asymmetric hydrogenation of 1,1-diarylethenes and 1,1-dialkylethenes with chiral iridium/spiro phosphine–oxazoline catalysts has been developed. A wide range of chiral diarylethanes and chiral γ-methyl fatty acids were synthesized with excellent enantioselectivity (see scheme).

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