Financial support from the Université Catholique de Louvain, FNRS, and Région Bruxelloise is gratefully acknowledged.
Copper/Palladium-Catalyzed 1,4 Reduction and Asymmetric Allylic Alkylation of α,β-Unsaturated Ketones: Enantioselective Dual Catalysis†
Article first published online: 4 FEB 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 11, pages 3208–3212, March 11, 2013
How to Cite
Nahra, F., Macé, Y., Lambin, D. and Riant, O. (2013), Copper/Palladium-Catalyzed 1,4 Reduction and Asymmetric Allylic Alkylation of α,β-Unsaturated Ketones: Enantioselective Dual Catalysis. Angew. Chem. Int. Ed., 52: 3208–3212. doi: 10.1002/anie.201208612
- Issue published online: 7 MAR 2013
- Article first published online: 4 FEB 2013
- Manuscript Revised: 19 DEC 2012
- Manuscript Received: 26 OCT 2012
- asymmetric allylic alkylation;
- dual catalysis;
- Michael acceptors;
Cooperative efforts: The catalytic coupling of the two organometallic intermediates is possible through a Cu/Pd-based dual catalysis (see scheme; LG=leaving group), in which the CuI catalytic cycle generates catalytically the starting material for the Pd0 catalytic cycle. Although reagents are present in stoichiometric amounts in the reaction mixture and are able to trap both active species, the desired reaction proceeds as planned.