We thank the Swiss National Science Foundation (A.D.), UCB-Celltech (C.D.S.), EPSRC (Z.G., Y.A.L.), and CRUK (Z.G.) for funding, and Profs V. Gouverneur and C. J. Schofield for helpful discussions. B.G.D. is a Royal Society Wolfson Merit Award recipient.
Self-Liganded Suzuki–Miyaura Coupling for Site-Selective Protein PEGylation†
Article first published online: 25 FEB 2013
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 14, pages 3916–3921, April 2, 2013
How to Cite
Dumas, A., Spicer, C. D., Gao, Z., Takehana, T., Lin, Y. A., Yasukohchi, T. and Davis, B. G. (2013), Self-Liganded Suzuki–Miyaura Coupling for Site-Selective Protein PEGylation . Angew. Chem. Int. Ed., 52: 3916–3921. doi: 10.1002/anie.201208626
- Issue published online: 26 MAR 2013
- Article first published online: 25 FEB 2013
- Manuscript Received: 26 OCT 2012
- Swiss National Science Foundation
- Suzuki-Miyaura coupling
Building with PEGs: PEG–boronic acids, in the presence of simple Pd sources, are capable of acting as direct and effective Suzuki reagents in 70–98 % yield. When combined with non-natural amino acids, they allow efficient and direct, site-selective PEGylation of proteins at predetermined positions under biologically compatible conditions without the need for exogenous ligands.