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Keywords:

  • catalysis;
  • PEGylation;
  • proteins;
  • Suzuki-Miyaura coupling
Thumbnail image of graphical abstract

Building with PEGs: PEG–boronic acids, in the presence of simple Pd sources, are capable of acting as direct and effective Suzuki reagents in 70–98 % yield. When combined with non-natural amino acids, they allow efficient and direct, site-selective PEGylation of proteins at predetermined positions under biologically compatible conditions without the need for exogenous ligands.