These authors contributed equally to this work.
Pd-Catalyzed C–H Olefination of (Hetero)Arenes by Using Saturated Ketones as an Olefin Source†
Article first published online: 7 DEC 2012
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 4, pages 1299–1303, January 21, 2013
How to Cite
Shang, Y., Jie, X., Zhou, J., Hu, P., Huang, S. and Su, W. (2013), Pd-Catalyzed C–H Olefination of (Hetero)Arenes by Using Saturated Ketones as an Olefin Source . Angew. Chem. Int. Ed., 52: 1299–1303. doi: 10.1002/anie.201208627
Financial support from the 973 Program (2011CB932404, 2011CBA00501), NSFC (20925102) is greatly appreciated.
- Issue published online: 15 JAN 2013
- Article first published online: 7 DEC 2012
- Manuscript Received: 26 OCT 2012
- 973 Program. Grant Numbers: 2011CB932404, 2011CBA00501
- NSFC. Grant Number: 20925102
- C–C coupling;
- C–H functionalization;
Tolerant: By using Pd(OAc)2/PCy3 as a catalyst, both electron-rich aromatic heterocycles and electron-deficient fluorobenzenes undergo the dehydrogenative cross-coupling with (hetero)aryl ethyl ketones in good yields. A broad range of functional groups is tolerated, thus providing a general method for the facile syntheses of chalcones or heterocyclic chalcone analogues. Furthermore, dialkyl ketones can also participate in this transformation.