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Directional Selection Precedes Conformational Selection in Ubiquitin–UIM Binding


  • This work was supported by the National Science Foundation (grant MCB-0918362).


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Meeting your match: The early molecular recognition event of ubiquitin with the ubiquitin-interacting motif (UIM) of Hrs protein starts out with a directional bias in the position of UIM, increasingly favoring directions facing the binding interface of ubiquitin as the distance decreases (see figure). This process, which is driven by electrostatic long-range interactions, precedes an internal conformational population shift.

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