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Keywords:

  • aldol reaction;
  • leucosceptroids;
  • Michael addition;
  • sesterterpenoids;
  • total synthesis
Thumbnail image of graphical abstract

Less stable, but natural: The asymmetric total synthesis of leucosceptroid B (see scheme) has been accomplished in 19 steps. Thermodynamically, this natural product proved to be less stable than its C11 epimer, a synthetic intermediate. This synthesis features a high degree of flexibility, facilitating its application to the preparation of a broad range of other natural derivatives.