Radio-Frequency Ionization of Organic Compounds for Mass Spectrometry Analysis


  • Financial support from the Institute for Therapeutic Discovery and Department of Defense (grant CDMRP-OC060322) is acknowledged. We thank Mahsan Miladi for assistance with preparing and positioning the ICR cell trap plates.


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A new ionization technique: A radio-frequency signal was used to ionize neutral organic molecules in the ultrahigh-vacuum region of a Fourier transform ion cyclotron resonance mass spectrometer. Radio-frequency ionization (RFI) yielded signal/noise (S/N) ratios roughly six times higher than those generated by conventional 70 eV electron impact ionization (EI).