Relay Catalytic Branching Cascade: A Technique to Access Diverse Molecular Scaffolds

Authors

  • Dr. Nitin T. Patil,

    Corresponding author
    1. Division of Crop Protection Chemicals, CSIR—Indian Institute of Chemical Technology, Hyderabad—500007 (India)
    • Division of Crop Protection Chemicals, CSIR—Indian Institute of Chemical Technology, Hyderabad—500007 (India)===

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  • Valmik S. Shinde,

    1. Division of Crop Protection Chemicals, CSIR—Indian Institute of Chemical Technology, Hyderabad—500007 (India)
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  • Dr. Balasubramanian Sridhar

    1. Laboratory of X-Ray Crystallography, CSIR—Indian Institute of Chemical Technology, Hyderabad–500007 (India)
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  • Generous financial support by the Department of Science and Technology (DST) and the Council of Scientific and Industrial Research (CSIR), New Delhi, India, is gratefully acknowledged. V.S.S. thanks the UGC for a senior research fellowship.

Abstract

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Skeletal diversity: The reactions of alkynoic acids (A, common type of substrates) with various scaffold-building agents (B) under gold catalysis produce a series of multifunctional polyheterocyclic structures (see scheme). The approach enables the preparation of compound libraries with high skeletal diversity.

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