Get access

Cooperative Catalysis through Noncovalent Interactions


  • We thank EPRSC for funding support to W.J.T. and S.J. on grant EP/G031444, the University of Liverpool for support of the NMR Centre for Structural Biology, and the EPSRC National Mass Spectrometry Service Centre for mass analysis.


original image

One of four: A chiral phosphoric acid enables asymmetric hydrogenation of imines with an achiral iridium catalyst by virtue of noncovalent interactions. These interactions lead to the formation of a highly organized ternary complex, and the hydride is transferred highly enantioselectively.