Tf2CH2 was kindly provided by the Central Glass Co., Ltd. This work was partially supported by a Grant-in-Aid for Scientific Research on Innovative Areas “Advanced Molecular Transformations by Organocatalysts” from the MEXT. We also thank the Asahi Glass Foundation.
Synthesis, Characterization, and Applications of Zwitterions Containing a Carbanion Moiety†
Article first published online: 13 DEC 2012
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Angewandte Chemie International Edition
Volume 52, Issue 5, pages 1560–1563, January 28, 2013
How to Cite
Yanai, H., Yoshino, T., Fujita, M., Fukaya, H., Kotani, A., Kusu, F. and Taguchi, T. (2013), Synthesis, Characterization, and Applications of Zwitterions Containing a Carbanion Moiety . Angew. Chem. Int. Ed., 52: 1560–1563. doi: 10.1002/anie.201208809
- Issue published online: 23 JAN 2013
- Article first published online: 13 DEC 2012
- Manuscript Received: 2 NOV 2012
- aldol reaction;
- homogeneous catalysis;
- synthetic methodology;
A trifle of triflyl: N-substituted anilines react with 1,1,3,3-tetrakis(triflyl)propane to give a 2,2-bis(triflyl)ethyl group at the para position of the ring. The product is a zwitterion with a carbanion and an ammonium moiety, and can be used as an acid catalyst for organic reactions (see scheme).